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Tirzepatide contains two polypeptides, one of which is an analog of GLP-1 and the other an analog of GIP. These analogs bind to and activate their corresponding receptors, essentially mimicking the effects of the naturally occurring incretins. In particular, tirzepatide activation of GLP-1 receptors improves glucose-mediated insulin secretion and decreases secretion of glucagon. Tirzepatide activation of GIP receptors augments insulin sensitivity and secretion and thereby helps reinforce the mechanisms regulating blood glucose levels. Owing to the drug’s additional effects, such as delayed gastric emptying and increased satiety after nutrient consumption, its use is further associated with reduced food intake and weight loss. In short it helps your body regulate sugar levels better and helps you feel full for longer period, compared to Semaglutide.